CHEM - Chemistry
Courses numbered 500 to 799 = undergraduate/graduate. (Individual courses may be limited to undergraduate students only.) Courses numbered 800 to 999 = graduate.
CHEM 514. Inorganic Chemistry (3).
General education advanced further study course. Basic inorganic chemistry emphasizing molecular symmetry and structure, fundamental bonding concepts, ionic interactions, periodicity of the elements, systematics of the chemistry of the elements, acid-base chemistry and non-aqueous solvents, classical coordination chemistry and introductory bioinorganic chemistry. Prerequisite: CHEM 212 with a grade higher than C-. CHEM 531 strongly suggested but not required.
CHEM 523. Analytical Chemistry (4).
2 Classroom hours; 6 Lab hours.
Lab fee. General education advanced further study course. Evaluation of data, theory and application of gravimetric analysis and precipitation, neutralization and oxidation-reduction volumetric analysis. Prerequisite: CHEM 212 with a grade higher than C-.
CHEM 524. Instrumental Methods of Chemical Analysis (4).
2 Classroom hours; 6 Lab hours.
Lab fee. Introduction to spectroscopic techniques (UV-Visible atomic absorption, molecular absorption, infrared, mass spectrometry and NMR), electrochemical techniques (potentiometry, voltammetry and coulometry) and separation techniques (gas chromatography and HPLC). Applications of computer and automated methods of analysis also covered. Prerequisite: CHEM 531. CHEM 532 strongly recommended but not required.
CHEM 531. Organic Chemistry I (5).
3 Classroom hours; 6 Lab hours.
Lab fee. General education advanced further study course. Introduction to the study of carbon compounds emphasizing reaction mechanisms, stereochemistry and spectrographic analysis. Credit is not allowed for both CHEM 531 and 535. Prerequisite: CHEM 212 with a grade higher than C-.
CHEM 532. Organic Chemistry II (5).
3 Classroom hours; 6 Lab hours.
Lab fee. A continuation of CHEM 531 emphasizing the structure and reactions of principal functional groups and compounds of biological interest. Credit is not allowed for both CHEM 532 and 536. Prerequisite: CHEM 531 with a grade higher than C-.
CHEM 533. Elementary Organic Chemistry (3).
A one semester survey of organic chemistry, examining various classes of organic compounds, organic reactions and reaction mechanisms. The goal of the course is to establish an understanding of the relationship between structure and reactivity, with particular emphasis on the importance of organic chemistry to the health sciences and biomedical engineering. Credit is not allowed for both CHEM 533 and 531. This course does not meet the needs of chemistry majors or premed students. Prerequisite: CHEM 212 with a grade higher than C-.
CHEM 535. Organic Chemistry I (3).
Introduction to the study of carbon compounds emphasizing reaction mechanisms, stereochemistry and spectrographic analysis. Credit is not allowed for both CHEM 535 and 531. This course does not include a lab, is open only to biomedical engineering majors and does not meet the needs of chemistry majors or premed students. Prerequisites: must be a biomedical engineering major and have completed CHEM 212 with a grade higher than C-.
CHEM 536. Organic Chemistry II (3).
Continuation of CHEM 535 emphasizing the structure and reactions of principal functional groups and compounds of biological interest. Credit is not allowed for both CHEM 536 and 532. This course does not include a lab, is open only to biomedical engineering majors and does not meet the needs of chemistry majors or premed students. Prerequisites: must be a biomedical engineering major and have completed CHEM 531 or 535 with a grade higher than C-.
CHEM 545. Physical Chemistry I (3).
General education advanced further study course. Introduction to the fundamentals of thermodynamics with the goal of understanding the driving forces behind chemical and physical changes and equilibria. Covers the laws of thermodynamics and explores concepts involving work, heat and simple mechanical processes. Helmholtz and Gibbs energy are introduced as thermodynamic indicators of spontaneity/equilibria. The last portion of the course applies these concepts to the study of phase changes, chemical equilibria, ideal and non-ideal solutions, electrolytes and chemical kinetics. Prerequisites: CHEM 212 with a grade higher than C-, one year of college physics, MATH 344 or its equivalent.
CHEM 546. Physical Chemistry II (3).
Covers elementary quantum mechanics and its applications to chemistry. Begins with a historical comparison between classical and quantum mechanics, then builds from the postulates of quantum mechanics to explore the Schrödinger equation and its use in solving problems involving particles, rotating bodies and vibrations. Special emphasis on spectroscopy and approximation methods relevant to chemistry. Prerequisites: CHEM 212 with a grade higher than C-, one year of college physics, and MATH 344 or its equivalent.
CHEM 547. Physical Chemistry Lab (2).
6 Lab hours.
Lab fee. Laboratory experiments and exercises that reinforce physical chemistry concepts of thermodynamics, equilibrium, spectroscopy and error analysis. Students gain practical, hands-on experience with computerized data acquisition and learn computational techniques for data reduction and analysis. Pre- or corequisites: CHEM 545, 546.
CHEM 605. Medicinal Chemistry (3).
For students interested in chemistry related to the design, development and mode of action of drugs. Describes those organic substances used as medicinal agents and explains the mode of action and chemical reactions of drugs in the body; illustrates the importance and relevance of chemical reactions as a basis of pharmacological activity, drug toxicity, allergic reactions, carcinogenicity, etc.; and brings about a better understanding of drugs. Includes transport, basic receptor theory, metabolic transformation of drugs, discussion of physical and chemical properties in relation to biological activity, drug design, structure-activity relationships and discussion of a select number of organic medicinal agents. Prerequisite: CHEM 532 or equivalent; a semester of biochemistry (CHEM 661 or 662) and a year of biology are strongly recommended.
CHEM 615. Advanced Inorganic Chemistry (3).
Includes modern bonding theories, structure and spectra of inorganic compounds, coordination and organometallic chemistry, boranes, inorganic ring systems and polymers, inorganic environmental chemistry, mechanisms of inorganic reactions and solid state chemistry. Prerequisite: CHEM 514. Pre- or corequisite: CHEM 546.
CHEM 616. Inorganic Chemistry Lab (2).
6 Lab hours.
Lab fee. Experimental methods of inorganic chemistry. Pre- or corequisite: CHEM 615.
CHEM 661. Introductory Biochemistry (3).
General education advanced further study course. An introductory course for chemistry majors including chemistry/business majors and students in life sciences. Not recommended for the BS in chemistry-premedicine or biochemistry field majors for whom CHEM 662 and 663 are required. Introduces thermodynamics and biological oxidation-reduction reactions; structure, metabolism and synthesis of proteins, carbohydrates, lipids and nucleic acids; enzyme kinetics, photosynthesis and transfer of genetic information. Prerequisite: CHEM 532, 533, or 536. Credit is not granted for both CHEM 661 and 662.
CHEM 662. Biochemistry I (3).
Study of major constituents of the cell: protein, carbohydrate, glycoprotein, lipid, nucleic acid, nucleoprotein, enzyme catalysis, biological oxidations, photosynthesis and introduction to intermediary metabolism. A fundamental background of biology or microbiology is recommended but not essential. Prerequisites: CHEM 523 and 532 or equivalents. Credit is not granted for both CHEM 661 and 662.
CHEM 663. Biochemistry II (3).
Study of metabolism and control of carbohydrates, lipids, phosphoglycerides, spingolipids, sterols, amino acids and proteins; synthesis of porphyrins, amides and polyamines; synthesis and metabolism of purines, pyrimidines and nucleotides; synthesis and structure of DNAs, RNAs and proteins; organization and functioning of genes; evolution of proteins and nucleic acids, hereditary disorders of metabolism, biochemistry of endocrine glands, major nutrients and vitamins, body fluids and generalized tissues. A fundamental background of biology or microbiology is recommended but not essential. Prerequisite: CHEM 662 with a grade higher than C-.
CHEM 664. Biochemistry Laboratory (3).
1 Classroom hour; 6 Lab hours.
Lab fee. Practical training in biochemical procedures and literature searching; experiments include isolation, characterization and assay of biomolecules and use of centrifugation, chromatography, electrophoresis, spectrophotometry, enzyme kinetics and molecular cloning techniques. Prerequisite: CHEM 532. Pre- or corequisite: CHEM 662 or 663.
CHEM 666. Special Topics in Biochemistry (3).
Discusses a small number of current problems in biochemistry in depth. Requires reading of published research in the field. (Offered fall semester in even-numbered years.) Prerequisites: BIOL 211, CHEM 662, 663.
CHEM 669. Research In Biochemistry (2).
Cross-listed as BIOL 669. Students in the biochemistry field major participate in a biochemistry research project under the direction of a faculty member. Requires a written report summarizing the results. May be repeated once for credit. Graded Cr/NCr. Prerequisites: BIOL 420, CHEM 662 or 663, and CHEM 664 and instructor's consent.
CHEM 690. Independent Study and Research (1-3).
Studies performed must be directed by a faculty member in the department of chemistry. For undergraduate students only. Repeatable for credit. A maximum of 3 credit hours may be counted toward graduation. Graded Cr/NCr. Prerequisite: departmental consent.
CHEM 700. Chemistry Seminar (1).
Students give seminars on either papers recently published in the literature or on their own research. Repeatable for credit. Graded S/U.
CHEM 701. Chemistry Colloquium (1).
Speakers for the colloquium consist of outstanding chemists from other institutions and faculty. Repeatable for credit. Graded S/U.
CHEM 709. Special Topics in Chemistry (2-3).
A discussion of topics of a special significance and interest to faculty and students. Offerings announced in advance. Repeatable for credit.
CHEM 715. Advanced Spectroscopy (3).
Introduction to 1H and 13C NMR spectroscopy including basic concepts such as integration, chemical shifts, diamagnetic shielding, magnetic anisotropy, spin-spin coupling (first and second-order), coupling constants, proton decoupled 13C NMR interpretation of 1H and 13C NMR spectra. More advanced topics include NOE and protein structural mapping, and multidimensional techniques such as COSY, DEPT, INEPT, molecular motion by NMR, coupling to I>0 metal centers, including those with <100 percent natural abundance, virtual coupling in metal complexes, NMR of paramagnetic systems and use of paramagnetic shift reagents. An introduction to mass spectroscopy including instrumentation-magnetic sector, quadrupole, ion trap, MS-MS; sample preparation and interfaces-GC-MS, LC-MS, electrospray, MALDI; methods of ionization-electron impact, chemical ionization, electrospray, interpretation of mass spectra-basic concepts, fragmentation patterns. An introduction to the interpretation of mid-infrared spectroscopy of complex molecules and ionic compounds followed by the synthesis of results from NMR, MS and mid IR spectra to determine structure. Emphasis on interpretation of results for understanding electronic and molecular properties of chemical compounds related to their symmetry. Prerequisite: CHEM 532 or equivalent; or admission to a chemistry graduate program.
CHEM 717. Advanced Spectroscopy II (3).
Introduction to electronic and vibrational spectroscopy, EPR and magnetic properties of compounds. A study of the electric field interaction of radiation, electronic and vibrational spectroscopy, and the magnetic field interaction of radiation, EPR and magnetism, with molecular systems examining the different changes in state that molecules can undergo. Emphasis on interpretation of results for understanding electronic and molecular properties of chemical compounds related to their symmetry and structure. Prerequisites: CHEM 532, 546, 615, or their equivalents; or admission to a chemistry graduate program.
CHEM 719. Modern Synthetic Methods (3).
Introduction to modern synthetic methods in chemistry. A detailed investigation of the synthetic chemistry of anions is followed by a detailed survey of functional group interconversions, then oxidation and reduction reactions. The topic of retrosynthetic analysis is introduced. Topics in inorganic synthesis include organometallic bond forming and breaking reactions, ligand synthesis and replacement, solid state synthesis and topics in bioinorganic synthesis. Prerequisites: CHEM 532 and 615, or their equivalents; or admission to a chemistry graduate program.
CHEM 721. Advanced Biochemistry (3).
Introduction to advanced biochemical concepts, processes and techniques. A comprehensive survey of structure and functions of biomolecules including proteins, nucleic acids, lipids, DNA replication and translation, biological membrane and membrane transport are covered. Enzyme mechanisms and kinetics and protein structure/function are discussed in detail. Biochemical, molecular biological, biophysical and chemical techniques that are commonly used in the study of biochemical processes are introduced and discussed. Prerequisite: CHEM 661 or 663 or their equivalents; or admission to a chemistry graduate program.
CHEM 722. Advanced Physical Chemistry (3).
In-depth overview of the fundamentals of thermodynamics, kinetics, quantum mechanics and statistical mechanics as they apply to chemistry. Special emphasis is placed on solution thermodynamics, kinetics of coupled reactions, statistical mechanics of macromolecules and quantum mechanics as it applies to spectroscopy. Prerequisites: CHEM 545 and 546, or their equivalents; or admission to a chemistry graduate program.
CHEM 734. Instrumental Methods for Research (3).
Designed to prepare graduate students or other researchers to perform spectroscopy experiments relevant to their research. The identity of organic compounds can be determined by the information provided by several types of spectra: mass, infrared, nuclear magnetic resonance, fluorescence and ultraviolet. Students learn to operate such instruments as the Varian 2200 GC/MS mass spectrometer, the ThermoNicolet Avatar FTIR spectrophotometer, the Varian Mercury 300 and Inova 400 NMR spectrometers, the Fluorolog fluorescence spectrophotometer and the Hitachi U-2010 and Varian Cary 100 UV-Vis spectrophotometers in the department's NMR and analytical facilities. The focus of this class is technique and not the interpretation of spectra. On successful completion of this course, students are authorized to use departmental instruments. Prerequisite: CHEM 524 or equivalent, or departmental consent, or admission to a chemistry graduate program.
CHEM 738. Structure Determination and Spectral Analysis of Organic Compounds (3).
Discusses chiroptical techniques, infrared, ultraviolet, nuclear magnetic and electron spin resonance and mass spectroscopy, and their practical use in structure determination. Prerequisite: CHEM 532.
CHEM 744. Computational Quantum Chemistry (3).
An introduction to molecular orbital procedures and methods for calculating a wide range of physical, chemical and electronic properties of systems large enough to be of interest to inorganic, organic and biochemists. Using commercial molecular orbital software programs such as MOPAC, SPARTAN and GAUSSIAN, students learn to select appropriate "model" computational procedures to predict properties of molecules and reactions. By comparison with experiment, students learn to assess the range of applicability and accuracy of the "model" methods as applied to various categories of chemical systems. Properties considered include energies and structures of molecules, ions and transition states; vibrational frequencies, IE and RAMAN spectra; thermochemical properties, heat of formation, bond and reaction energies, isomerization energy barriers, reaction pathways; molecular orbitals, atomic charges, dipole and multipole moments, ionization potentials, bond orders; orbital energies and photoelectron spectroscopy; excited state properties, singlet and triplet surfaces. Prerequisite: CHEM 546 or equivalent (MATH 344 is necessary).
CHEM 809. Special Studies in Chemistry (2-3).
Systematic study in selected areas of chemistry. Repeatable for credit. Course content differs from one offering to the next.
CHEM 815. Bioinorganic Chemistry (3).
The study of the role of inorganic chemistry in biological systems. Includes electron transport, biological catalysis mediated by metal ions, metal storage and transport, ion transport, and the role of transition metals in metabolism. Prerequisites: CHEM 615, 663 or equivalents.
CHEM 823. Analytical Spectroscopy (3).
Absorption (UV visible, IR, and atomic); emission: flame emission and atomic absorption spectrometry, molecular fluorescence, and phosphorescence methods; Raman, nuclear magnetic resonance, and electron spin resonance spectroscopy; X-ray methods. Lectures and discussions on theory and practice. Particular emphasis on instrumentation and the acquisition of artifact-free data. Prerequisite: CHEM 524 or equivalent.
CHEM 835. Bio-organic Chemistry (3).
CHEM 863. Analytical Biochemistry (3).
A review of modern analytical methods used in biochemistry and molecular biology including absorbance and fluorescence spectroscopy chromatography (affinity, gel-filtration, HPLC, ion-exchange, ion-pair), gel electrophoresis, radioactive tracer methods; cloning, sequencing and recombinant DNA procedures. Prerequisites: BIOL 210, 211, and CHEM 662 or 663 or equivalents.
CHEM 890. Research in Chemistry (1-12).
Research for the student planning to receive an MS. Research is directed by a faculty member. Repeatable for credit. Graded S/U.
CHEM 990. Research in Chemistry (1-11).
Research for the student planning to receive the PhD. Research is directed by a faculty member. Repeatable for credit. Graded S/U.